INGX (inhibitor of growth family, X-linked, pseudogene)
نویسندگان
چکیده
منابع مشابه
Decreased placental X-linked inhibitor of apoptosis protein in an ovine model of intrauterine growth restriction.
OBJECTIVE The objective of the study was to assess placental apoptosis at both midgestation and near term in an ovine model of placental insufficiency (PI) and intrauterine growth restriction (IUGR). STUDY DESIGN At 40 days' gestational age (dGA), 2 groups of 4 ewes were exposed to hyperthermic conditions for either 55 days or 80 days to induce IUGR with necropsies at 95 (midgestation) and 13...
متن کاملX-linked inhibitor of apoptosis protein functions as a cofactor in transforming growth factor-beta signaling.
X-linked inhibitor of apoptosis protein (XIAP) is a potent suppressor of apoptotic cell death, which functions by directly inhibiting caspases, the principal effectors of apoptosis. Here we report that XIAP can also function as a cofactor in the regulation of gene expression by transforming growth factor-beta (TGF-beta). XIAP, but not the related proteins c-IAP1 or c-IAP2, associated with sever...
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In this paper we consider the dynamics of the real polynomials of degree d + 1 with a fixed point of multiplicity d ≥ 2. Such polynomials are conjugate to fa,d(x) = axd(x−1)+x, a ∈ R{0}, d ∈ N. Our aim is to study the dynamics fa,d in some special cases.
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X-linked inhibitor of apoptosis (XIAP), first identified in 1996 (1), is a member of the IAP family of endogenous caspase inhibitors that blocks the execution of apoptosis. The inhibitory function of XIAP can be reversed by its antagonists, whereas its abundance can be regulated in a proteasomedependent manner. In less than a decade, great strides made in understanding basic XIAP function has t...
متن کاملX-linked inhibitor of apoptosis regulates T cell effector function.
To understand how the balance between pro- and anti-apoptotic signals influences effector function in the immune system, we studied the X-linked inhibitor of apoptosis (XIAP), an endogenous regulator of cellular apoptosis. Real-time PCR showed increased XIAP expression in blood of mice with experimental autoimmune encephalomyelitis, correlating with disease severity. Daily administration (10 mg...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2014
ISSN: 1768-3262
DOI: 10.4267/2042/54008